Marble Burying Compulsive Behavior

Disease head injury genetic modifications and treatment of mice with drugs can have profound effects on behavior.

Marble burying compulsive behavior.

When put in a cage with marbles mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging while mice with a high degree of anxiety tend to engage in a high degree of digging in. However modulation of marble burying by serotonin reuptake inhibitors prompted its link to obsessive compulsive disorder compulsive like behavior. Marble burying is an animal model used in scientific research to depict anxiety or obsessive compulsive disorder ocd behavior. The marble burying and nestlet shredding tests are good examples of behavioral methods for studying repetitive and compulsive like behaviors in mice.

Numerous animal models for evaluating compulsive like behaviors have been developed over the past three decades. While widely used there is significant controversy over the interpretation of its results. It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. The marble burying behavior test is an acute test.

Hallmark features of ocd patients are similarities and more prominent differences from anxiety disorders e g the absence of sex differences and resistance to spontaneous remission. Marble burying is considered an albeit controversial animal model of the compulsive like behaviors of obsessive compulsive disorder ocd. Perhaps the animal models with the greatest validity and ease of use are the marble burying test and the nestlet shredding test. Both tests take advantage of the fact that the target behaviors occur spontaneously in mice.

However some investigators incorporate the sub acute treatment regimen as an essential component for screening anti compulsive agents. The marble burying test is a useful model of both obsessive compulsive like ocd behavior and or anxiety like behavior. Large nest building lnb and high marble burying hmb which may be relevant to understanding the neurobiology of different symptom dimensions in obsessive compulsive and related disorders. Both tests show excellent face construct and predictive validity for the human disorders they model 6 11.

Considered together with the results from. Marble burying is considered an albeit controversial animal model of the compulsive like behaviors of obsessive compulsive disorder ocd. Hallmark features of ocd patients are similarities and more prominent differences from anxiety disorders e g the absence of sex differences and resistance to spontaneous remission.