Marble Burying Problems

However modulation of marble burying by serotonin reuptake inhibitors prompted its link to obsessive compulsive disorder compulsive like behavior.

Marble burying problems.

The 1 3 ns finding that marble burying was constant across several exposures at different times of day suggests that burying behavior has no clear diurnal pattern. The marble burying behavior test is an acute test. 1 3 since the bulk of this work was done using female mice the 1 1 ns finding that males have the same propensity to bury marbles shows 1 5 ns that the behavior is not peculiar to. It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding.

It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19. A primary advantage of the marble burying and nestlet shredding tests is the fact that each depends on natural and spontaneous behaviors of mice that can be quantified after test completion allowing a single investigator to set up an experiment and then remain outside of the testing room until sessions end. The marble burying test is commonly used to quantify anxiety obsessive compulsive or repetitive behaviour in rodents 1 3 performance on the marble burying test is also associated with general digging behaviour 4 7 and so the underlying construct being measured is still unclear regardless the typical protocol places 10 25 marbles in a cage containing sawdust or similar. However some investigators incorporate the sub acute treatment regimen as an essential component for screening anti compulsive agents.