Marble Burying Test Wiki

Disease head injury genetic modifications and treatment of mice with drugs can have profound effects on behavior.

Marble burying test wiki.

The validity of the marble burying test is quite controversial. This can be counteracted by coating marbles with substances such as tabasco sauce which will. Zimeldine 10 0 mg kg reduced marble burying without affecting locomotor activity. Some strains show decreased burying behaviour.

The test exhibits between laboratory methodological differences and demonstrates positive treatment responses to an array of pharmacotherapies creating doubts. We tested the possibility that a genetic component underlies marble burying in mice and if there is a genetic correlation with other anxiety like traits. Of duration of marbles buried test s mean sem time of nonmarble side s mean sem time nonmarble side 300 600 1800 4 2 2 0 7 3 0 9 8 4 0 4 143 4 292 30 916 45 47 ns 49 ns 51 ns data from 10 female. However some investigators incorporate the sub acute treatment regimen as an essential component for screening anti compulsive agents.

The marble burying behavior test is an acute test. Utilizing well characterized and validated approaches such as marble burying and nestlet shredding compulsive like behaviors can be documented accurately in mice as models of human obsessive compulsive disorder and autism spectrum disorder. Fig 1 the ck1ε inhibitor pf 670462 shows anxiolytic activity in the marble burying test. Marble burying behavior gauges the level of anxiety in a mouse when it encounters unfamiliar objects.

The animal is then placed in the cage containing the marbles. Thus the general consensus is to perform a battery of anxiety tests with a high predictive validity to determine the potential therapeutic value of a novel agent. Since findings reported in the literature indicate that marble burying behavior. The mouse is treated with the vehicle or compound 30 minutes before the test.

An increasing number of investigators utilize the marble burying assay despite the paucity of information available regarding what underlies the behavior. This test is used for evaluation of anxiolytic effect of a. Gene editing eases the frantic burying of marbles bottom right in a mouse model of fragile x syndrome bottom left. Marble burying test is one of the models for evaluation of psychotropic and neurotropic activity.

Following the last baseline behavioral screen the bedding material of the 18 n and the 18 h animals was exchanged with sawdust. Marbles are placed evenly onto the walls of an empty cage. There is also a genetic component to this test. The marble burying test measures one acute dose of anti anxiety agent for thirty minutes.